基因名：
BAG1
产品别名：
BAG-1； HAP； RAP46； BAG1； BAG cochaperone 1； BAG cochaperone 1； BAG family molecular chaperone regulator 1； BCL2 associated athanogene 1； BCL2-associated athanogene； Bcl-2 associating athanogene-1 protein； Bcl-2-binding protein； glucocortoid receptor-associated protein RAP46； receptor-associated protein, 46-KD； Bcl2关联永生基因1(BAG1)； 抑凋亡基因bag1；
背景信息：
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq].
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
