基因名：
BCL2L1
产品别名：
BCL-XL/S； BCL2L； BCLX； Bcl-X； PPP1R52； BCL2L1； BCL2 like 1； BCL2 like 1； bcl-2-like protein 1； apoptosis regulator Bcl-X； protein phosphatase 1, regulatory subunit 52； B-细胞淋巴瘤因子2样蛋白(Bcl2L)； Bcl-xL蛋白； 磷酸化Bcl-xL(Ser62)； 磷酸化Bcl-xL蛋白；
背景信息：
Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.
