基因名：
HCN2
产品别名：
BCNG-2； BCNG2； EIG17； FEB2； GEFSP11； HAC-1； HCN2； hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2； hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2； potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2； brain cyclic nucleotide-gated channel 2； hyperpolarization activated cyclic nucleotide gated potassium channel 2； 环化核苷酸调控阳离子通道蛋白亚型2/4； 钾/钠超极化激活环核苷酸门控通道蛋白2；
背景信息：
Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1–4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif (1). HCN channels are expressed in the brain, heart, thalamus and testis (1). The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart (1). The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively (2,3). The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively (4,5).
