基因名：
BRAF
产品别名：
B-RAF1； B-raf； BRAF-1； BRAF1； NS7； RAFB1； BRAF； B-Raf proto-oncogene, serine/threonine kinase； B-Raf proto-oncogene, serine/threonine kinase； serine/threonine-protein kinase B-raf； 94 kDa B-raf protein； B-Raf proto-oncogene serine/threonine-protein kinase (p94)； B-Raf serine/threonine-protein； murine sarcoma viral (v-raf) oncogene homolog B1； proto-oncogene B-Raf； v-raf murine sarcoma viral oncogene homolog B； v-raf murine sarcoma viral oncogene homolog B1； B-Raf原癌基因丝氨酸/苏氨酸蛋白激酶(BRAF)； 磷酸化B-Raf；
背景信息：
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
