重组乳腺癌易感基因2蛋白

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重组乳腺癌易感基因2蛋白

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重组乳腺癌易感蛋白2(BRCA2)
Recombinant BRCA2

基因名：

BRCA2

产品别名：

BRCC2； BROVCA2； FACD； FAD； FAD1； FANCD； FANCD1； GLM3； PNCA2； XRCC11； BRCA2； BRCA2 DNA repair associated； BRCA2 DNA repair associated； breast cancer type 2 susceptibility protein； BRCA1/BRCA2-containing complex, subunit 2； DNA repair-associated BRCA2； Fanconi anemia group D1 protein； breast and ovarian cancer susceptibility gene, early onset； breast and ovarian cancer susceptibility protein 2； breast cancer 2 tumor suppressor； breast cancer 2, early onset； mutant BRCA2； mutant DNA repair-associated protein 2；乳腺癌易感基因2；乳腺癌易感蛋白2(BRCA2)；

背景信息：

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.