基因名：
BST1
产品别名：
CD157； cADPR2； BST1； bone marrow stromal cell antigen 1； bone marrow stromal cell antigen 1； ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2； ADP-ribosyl cyclase 2； NAD(+) nucleosidase； bone marrow stromal antigen 1； cADPr hydrolase 2； cyclic ADP-ribose hydrolase 2； 骨髓基质干细胞抗原1； 骨髓基质细胞抗原1(BST1)；
背景信息：
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.
