基因名：
C4A
产品别名：
C4； C4A2； C4A3； C4A4； C4A6； C4AD； C4S； CO4； CPAMD2； RG； C4A； complement C4A (Rodgers blood group)； complement C4A (Rodgers blood group)； complement C4-A； C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2； C4A anaphylatoxin； MHC class III region complement； Rodgers form of C4； acidic C4； acidic complement C4； complement component 4A (Rodgers blood group)； 补体C4γ链蛋白； 补体C4a+C4b蛋白； 补体C4b-A蛋白； 补体C4d-A蛋白； 补体成分4a(C4a)； 过敏毒素C4/补体C4；
背景信息：
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
