基因名：
CACNA1S
产品别名：
CACNL1A3； CCHL1A3； Cav1.1； HOKPP； HOKPP1； MHS5； TTPP1； hypoPP； CACNA1S； calcium voltage-gated channel subunit alpha1 S； calcium voltage-gated channel subunit alpha1 S； voltage-dependent L-type calcium channel subunit alpha-1S； calcium channel, voltage-dependent, L type, alpha 1S subunit； dihydropyridine receptor alpha 1 subunit； dihydropyridine-sensitive L-type calcium channel alpha-1 subunit； voltage-gated calcium channel subunit alpha Cav1.1； L-型电压依赖钙离子通道α1S亚基(CACNa1S)； 电压依赖性钙通道Cav1.1；
背景信息：
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
