基因名：
CASP9
产品别名：
APAF-3； APAF3； ICE-LAP6； MCH6； PPP1R56； CASP9； caspase 9； caspase 9； caspase-9； ICE-like apoptotic protease 6； apoptotic protease MCH-6； apoptotic protease activating factor 3； caspase 9, apoptosis-related cysteine peptidase； protein phosphatase 1, regulatory subunit 56； 半胱胺酸蛋白酶蛋白9-p10； 活化半胱胺酸蛋白酶蛋白-9； 磷酸化半胱氨酸蛋白酶9； 胱天蛋白酶9(CASP9)；
背景信息：
Caspase 9 (also known as ICE like apoptotic protease 6 (ICE LAP6), apoptotic protease Mch6, and apoptotic protease activating factor 3 (Apaf3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, BclXL, cIAP1, cIAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf1/cytochrome c complex, and following cleavage by Apaf1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase 10 into large p37 and small p10 subunits. Caspase 9 intereacts with BIRC7 and has been shown to cleave PARP and vimentin.
