基因名：
CBL
产品别名：
C-CBL； CBL2； FRA11B； NSLL； RNF55； CBL； Cbl proto-oncogene； Cbl proto-oncogene； E3 ubiquitin-protein ligase CBL； Cas-Br-M (murine) ecotropic retroviral transforming sequence； Cbl proto-oncogene, E3 ubiquitin protein ligase； RING finger protein 55； RING-type E3 ubiquitin transferase CBL； casitas B-lineage lymphoma proto-oncogene； fragile site, folic acid type, rare, fra(11)(q23.3)； oncogene CBL2； proto-oncogene c-Cbl； signal transduction protein CBL； 原癌基因CBL2； 原癌蛋白CBL2； 环指蛋白55(RNF55)； 磷酸化原癌基因CBL2； 磷酸化原癌蛋白CBL2；
背景信息：
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
