基因名:
CCKBR
产品别名:
CCK-B; CCK2R; GASR; CCKBR; cholecystokinin B receptor; cholecystokinin B receptor; gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK2 receptor; cholecystokinin-2 receptor; gastrin receptor; 促胃泌素受体; 胆囊收缩素B受体(CCKBR);
背景信息:
Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.