基因名：
CDK5
产品别名：
LIS7； PSSALRE； CDK5； cyclin dependent kinase 5； cyclin dependent kinase 5； cyclin-dependent kinase 5； TPKII catalytic subunit； cell division protein kinase 5； cyclin-dependent-like kinase 5； epididymis secretory sperm binding protein； protein kinase CDK5 splicing； serine/threonine-protein kinase PSSALRE； tau protein kinase II catalytic subunit； 周期素依赖性激酶5； 周期素依赖性激酶5(CDK5)； 磷酸化周期素依赖性激酶5；
背景信息：
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
