基因名：
CDKN1B
产品别名：
CDKN4； KIP1； MEN1B； MEN4； P27KIP1； CDKN1B； cyclin dependent kinase inhibitor 1B； cyclin dependent kinase inhibitor 1B； cyclin-dependent kinase inhibitor 1B； cyclin-dependent kinase inhibitor 1B (p27, Kip1)； P27/周期素依赖激酶抑制剂； 周期素依赖性激酶抑制因子1B(CDKN1B)； 周期素依赖性激酶抑制因子1B(CDKN1B)真核蛋白； 磷酸化P27/周期素依赖激酶抑制剂；
背景信息：
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.
