基因名：
AKR1C4
产品别名：
3-alpha-HSD； C11； CDR； CHDR； DD-4； DD4； HAKRA； AKR1C4； aldo-keto reductase family 1 member C4； aldo-keto reductase family 1 member C4； aldo-keto reductase family 1 member C4； 3-alpha-HSD1； 3alpha-hydroxysteroid 3-dehydrogenase； chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4； dihydrodiol dehydrogenase isozyme DD4； type I 3-alpha-hydroxysteroid dehydrogenase； 羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ；
背景信息：
Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.
