基因名：
CHGA
产品别名：
CGA； PHE5； PHES； CHGA； chromogranin A； chromogranin A； chromogranin-A； SP-I； betagranin (N-terminal fragment of chromogranin A)； catestatin； chromofungin； parathyroid secretory protein 1； pituitary secretory protein I； 嗜铬粒素A； 嗜铬粒素A蛋白； 嗜铬蛋白A(CHGA)； 嗜铬蛋白A(CHGA)真核蛋白；
背景信息：
Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation . Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress .
