基因名：
CMKLR1
产品别名：
CHEMERINR； ChemR23； DEZ； RVER1； CMKLR1； chemerin chemokine-like receptor 1； chemerin chemokine-like receptor 1； chemerin-like receptor 1； G-protein coupled receptor ChemR23； G-protein coupled receptor DEZ； chemerin receptor； chemokine receptor-like 1； chemokine-like receptor 1； orphan G-protein coupled receptor, Dez； resolvin E1 receptor； 趋化样因子受体1；
背景信息：
Chemokine-Like Receptor 1 (CMKLR1) is a serpentine transmembrane G-protein linked receptor. It is an orphan chemoattractant receptor, also known as ChemR23 or DEZ. CMKLR1 is expressed on the surface of monocyte-derived immature dendritic cells and peripheral plamacytoid dendritic (pDC) cells; but not on myeloid dendritic (mDC) cells, monocytes and lymphocytes. The expression of CMKLR1 on pDC is down-regulated after activation. Chemerin (TIG2) is a natural ligand of CMKLR1. The interaction of CMKLR1 with Chemerin induces pDC activation and chemotaxis. It has been shown that CMKLR1 is a coreceptor for several strains of SIV and HIV-1. CMKLR1 is a potential useful marker for distinguishing pDCs and mDCs.
