基因名：
ABCC2
产品别名：
ABC30； CMOAT； DJS； MRP2； cMRP； ABCC2； ATP binding cassette subfamily C member 2； ATP binding cassette subfamily C member 2； ATP-binding cassette sub-family C member 2； ATP-binding cassette, sub-family C (CFTR/MRP), member 2； canalicular multidrug resistance protein； canalicular multispecific organic anion transporter 1； multidrug resistance-associated protein 2； ATP结合盒转运蛋白C2(ABCC2)； 多药耐药相关蛋白2；
背景信息：
multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family.
