基因名：
CRK
产品别名：
CRKII； p38； CRK； CRK proto-oncogene, adaptor protein； CRK proto-oncogene, adaptor protein； adapter molecule crk； proto-oncogene c-Crk； v-crk avian sarcoma virus CT10 oncogene homolog； v-crk sarcoma virus CT10 oncogene-like protein； 磷酸化CRK； 磷酸化Crk p38；
背景信息：
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
