基因名：
CSE1L
产品别名：
CAS； CSE1； XPO2； CSE1L； chromosome segregation 1 like； chromosome segregation 1 like； exportin-2； CSE1 chromosome segregation 1-like； cellular apoptosis susceptibility protein； chromosome segregation 1-like protein； epididymis secretory sperm binding protein； exp2； importin-alpha re-exporter； 细胞凋亡敏感性基因；
背景信息：
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
