基因名：
CYBA
产品别名：
CGD4； p22-PHOX； CYBA； cytochrome b-245 alpha chain； cytochrome b-245 alpha chain； cytochrome b-245 light chain； cytochrome b light chain； cytochrome b(558) alpha chain； cytochrome b(558) alpha-subunit； cytochrome b, alpha polypeptide； cytochrome b-245, alpha polypeptide； cytochrome b558 subunit alpha； flavocytochrome b-558 alpha polypeptide； neutrophil cytochrome b 22 kDa polypeptide； p22 phagocyte B-cytochrome； p22phox； superoxide-generating NADPH oxidase light chain subunit； 细胞色素b245轻链；
背景信息：
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane, where they associate with the flavocytochrome cytochrome b558 to form the active enzyme complex. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions.
