基因名：
CYBB
产品别名：
AMCBX2； CGD； CGDX； GP91-1； GP91-PHOX； GP91PHOX； IMD34； NOX2； p91-PHOX； CYBB； cytochrome b-245 beta chain； cytochrome b-245 beta chain； cytochrome b-245 heavy chain； CGD91-phox； NADPH oxidase 2； cytochrome b(558) subunit beta； cytochrome b-245 beta polypeptide； cytochrome b558 subunit beta； heme-binding membrane glycoprotein gp91phox； neutrophil cytochrome b 91 kDa polypeptide； p22 phagocyte B-cytochrome； superoxide-generating NADPH oxidase heavy chain subunit； NADPH氧化酶2； 细胞色素b-245β肽(CYBb)；
背景信息：
NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.
