基因名：
CYP7A1
产品别名：
CP7A； CYP7； CYPVII； CYP7A1； cytochrome P450 family 7 subfamily A member 1； cytochrome P450 family 7 subfamily A member 1； cytochrome P450 7A1； 24-hydroxycholesterol 7-alpha-hydroxylase； cholesterol 7-alpha-hydroxylase； cholesterol 7-alpha-monooxygenase； cholesterol 7alpha-hydroxylase； cytochrome P450, family 7, subfamily A, polypeptide 1； cytochrome P450, subfamily VIIA polypeptide 1； 细胞色素P450 7A1/胆固醇7a羟化酶； 细胞色素P450家族成员7A1(CYP7A1)；
背景信息：
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010].
