基因名：
CYP26A1
产品别名：
CP26； CYP26； P450RAI； P450RAI1； CYP26A1； cytochrome P450 family 26 subfamily A member 1； cytochrome P450 family 26 subfamily A member 1； cytochrome P450 26A1； P450, retinoic acid-inactivating, 1； cytochrome P450 retinoic acid-inactivating 1； cytochrome P450, family 26, subfamily A, polypeptide 1； cytochrome P450, subfamily XXVIA, polypeptide 1； cytochrome P450RAI； hP450RAI； retinoic acid 4-hydroxylase； retinoic acid-metabolizing cytochrome； 细胞色素cP450 CYP26A1； 细胞色素P450家族成员26A1(CYP26A1)；
背景信息：
The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.
