基因名：
GADD45A
产品别名：
DDIT1； GADD45； GADD45A； growth arrest and DNA damage inducible alpha； growth arrest and DNA damage inducible alpha； growth arrest and DNA damage-inducible protein GADD45 alpha； DDIT-1； DNA damage-inducible transcript 1 protein； DNA damage-inducible transcript-1； growth arrest and DNA-damage-inducible 45 alpha； 生长停滞DNA损伤可诱导蛋白α(GADD45a)； 生长抑制DNA损伤基因45；
背景信息：
Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating DNA excision repair in vitro and inhibits entry of cells into S phase.
