基因名:
DDX3X
产品别名:
CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102; MRXSSB; DDX3X; DEAD-box helicase 3 X-linked; DEAD-box helicase 3 X-linked; ATP-dependent RNA helicase DDX3X; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; helicase-like protein 2; 三磷酸腺苷依赖解旋酶DDX3; 磷酸化三磷酸腺苷依赖解旋酶DDX3;
背景信息:
DDX3 is involved in RNA metabolism. Two DDX3 paralogs are found in humans; DDX3X is encoded by a gene found on the X chromosome while DDX3Y is encoded by a gene on the Y chromosome. DDX3Y is exclusively expressed in testis and is required for normal spermatogenesis. DDX3X is ubiquitously expressed and predominantly localizes to the nuclear speckles, participating in RNA splicing, transcription, translation initiation, mRNA transport and cell cycle regulation. DDX3X also partakes in HIV-1 replication and hepatitis C viral infections.