基因名：
DFFA
产品别名：
DFF-45； DFF1； ICAD； DFFA； DNA fragmentation factor subunit alpha； DNA fragmentation factor subunit alpha； DNA fragmentation factor subunit alpha； DFF45； DNA fragmentation factor 45 kDa subunit； DNA fragmentation factor, 45kDa, alpha polypeptide； inhibitor of CAD； Caspase激活的脱氧核糖核酸酶抑制剂； DNA片段化因子亚基α(DFFa)；
背景信息：
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
