基因名：
DHCR24
产品别名：
DCE； Nbla03646； SELADIN1； seladin-1； DHCR24； 24-dehydrocholesterol reductase； 24-dehydrocholesterol reductase； delta(24)-sterol reductase； 3 beta-hydroxysterol delta 24-reductase； desmosterol-to-cholesterol enzyme； diminuto/dwarf1 homolog； seladin 1； selective AD indicator 1； 24脱氢胆固醇还原酶；
背景信息：
Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone).
