基因名：
DLG4
产品别名：
MRD62； PSD95； SAP-90； SAP90； DLG4； discs large MAGUK scaffold protein 4； discs large MAGUK scaffold protein 4； disks large homolog 4； Tax interaction protein 15； discs large homolog 4； post-synaptic density protein 95； synapse-associated protein 90； Discs大同源物4(DLG4)； 磷酸化突触后密度蛋白95； 突触后密度蛋白95；
背景信息：
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
