基因名:
DMRT1
产品别名:
CT154; DMT1; DMRT1; doublesex and mab-3 related transcription factor 1; doublesex and mab-3 related transcription factor 1; doublesex- and mab-3-related transcription factor 1; DM domain expressed in testis 1; DM domain expressed in testis protein 1; DMRT1蛋白;
背景信息:
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]