基因名：
DPP6
产品别名：
DPL1； DPPX； MRD33； VF2； DPP6； dipeptidyl peptidase like 6； dipeptidyl peptidase like 6； dipeptidyl aminopeptidase-like protein 6； DPP VI； dipeptidyl aminopeptidase IV-related protein； dipeptidyl peptidase IV-related protein； dipeptidyl peptidase VI； dipeptidyl-peptidase 6； 二肽基肽酶6； 二肽基肽酶6(DPP6)；
背景信息：
DPP6 is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.
