基因名：
DUSP1
产品别名：
CL100； HVH1； MKP-1； MKP1； PTPN10； DUSP1； dual specificity phosphatase 1； dual specificity phosphatase 1； dual specificity protein phosphatase 1； CL 100； MAP kinase phosphatase 1； dual specificity protein phosphatase hVH1； mitogen-activated protein kinase phosphatase 1； protein-tyrosine phosphatase CL100； serine/threonine specific protein phosphatase； 丝裂原活化蛋白激酶磷酸酶-1； 双特异性磷酸酶1(DUSP1)； 磷酸化丝裂原活化蛋白激酶磷酸酶-1； 磷酸化丝裂原活化蛋白激酶磷酸酶1；
背景信息：
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.
