基因名:
DUSP2
产品别名:
PAC-1; PAC1; DUSP2; dual specificity phosphatase 2; dual specificity phosphatase 2; dual specificity protein phosphatase 2; dual specificity protein phosphatase PAC-1; serine/threonine specific protein phosphatase; 双特异性磷酸酶2;
背景信息:
DUSP2 is a dual-specific thr/tyr phosphatase that is a physiologically relevant MAP kinase phosphatase. The gene is located on 2q11.2-q11 and contains 4 exons that span approximately 2.3kb. Under specific stress conditions, p53 regulates transcription of PAC1 through a new p53-binding site, and that PAC1 is necessary and sufficient for p53-mediated apoptosis.