基因名：
EFNA1
产品别名：
B61； ECKLG； EFL1； EPLG1； GMAN； LERK-1； LERK1； TNFAIP4； EFNA1； ephrin A1； ephrin A1； ephrin-A1； TNF alpha-induced protein 4； eph-related receptor tyrosine kinase ligand 1； epididymis secretory sperm binding protein； gastric cancer metastasis associated long noncoding RNA； immediate early response protein B61； ligand of eph-related kinase 1； tumor necrosis factor, alpha-induced protein 4； 内皮细胞受体蛋白酪氨酸激酶A/肿瘤坏死因子α诱导蛋白4； 肝配蛋白A1(EFNA1)；
背景信息：
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization.
