基因名：
EGFR
产品别名：
ERBB； ERBB1； ERRP； HER1； NISBD2； PIG61； mENA； EGFR； epidermal growth factor receptor； epidermal growth factor receptor； epidermal growth factor receptor； EGFR vIII； avian erythroblastic leukemia viral (v-erb-b) oncogene homolog； cell growth inhibiting protein 40； cell proliferation-inducing protein 61； epidermal growth factor receptor tyrosine kinase domain； erb-b2 receptor tyrosine kinase 1； proto-oncogene c-ErbB-1； receptor tyrosine-protein kinase erbB-1； EGFR/HER1蛋白； 磷酸化表皮生长因子受体； 表皮生长因子受体； 表皮生长因子受体(EGFR)； 表皮生长因子受体(EGFR)真核蛋白； 表皮生长因子受体III型突变体； 表皮生长因子受体蛋白；
背景信息：
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.
