基因名：
EIF2S1
产品别名：
EIF-2； EIF-2A； EIF-2alpha； EIF2； EIF2A； EIF2S1； eukaryotic translation initiation factor 2 subunit alpha； eukaryotic translation initiation factor 2 subunit alpha； eukaryotic translation initiation factor 2 subunit 1； eIF-2-alpha； eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa； 真核启动因子2α(eIFα2)； 真核翻译起始因子2亚基1(EIF2S1)； 磷酸化真核启动因子2α；
背景信息：
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010].
