基因名：
ELF3
产品别名：
EPR-1； ERT； ESE-1； ESX； ELF3； E74 like ETS transcription factor 3； E74 like ETS transcription factor 3； ETS-related transcription factor Elf-3； E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)； E74-like factor 3 (ets domain transcription factor)； E74-like factor 3 (ets domain transcription factor, epithelial-specific )； epithelial-restricted with serine box； epithelium-restricted Ets protein ESX； epithelium-specific Ets transcription factor 1； ets domain transcription factor, serine box (epithelial-specific)； 上皮细胞特异性转录因子1；
背景信息：
ESE-1, a member of the Ets family of transcription factors, critically regulates epithelial cell differentiation and mediates vascular inflammation. ESE-1 is strongly expressed in vascular endothelium and smooth muscle cells where it is induced in response to inflammatory cytokines and lipopolysaccharides, interacts with NF-KappaB to induce nitric oxide synthase, and is induced during terminal differentiation of epidermal and primary keratinocytes. In addition, ESE-1 is upregulated upon differentiation of corneal epithelium and interacts with Sp1 and AP-1 proteins to induce squamous differentiation marker expression in bronchial epithelial cells.
