基因名：
EPAS1
产品别名：
ECYT4； HIF2A； HLF； MOP2； PASD2； bHLHe73； EPAS1； endothelial PAS domain protein 1； endothelial PAS domain protein 1； endothelial PAS domain-containing protein 1； EPAS-1； HIF-1-alpha-like factor； HIF-1alpha-like factor； HIF-2-alpha； HIF2-alpha； PAS domain-containing protein 2； basic-helix-loop-helix-PAS protein MOP2； class E basic helix-loop-helix protein 73； hypoxia-inducible factor 2 alpha； member of PAS protein 2； 低氧诱导因子2α(HIF2a)； 缺氧诱导因子2α/HIF-2α/HIF-2-alpha；
背景信息：
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
