基因名:
EPHA5
产品别名:
CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4; EPHA5; EPH receptor A5; EPH receptor A5; ephrin type-A receptor 5; EPH homology kinase 1; EPH-like kinase 7; brain-specific kinase; epididymis secretory sperm binding protein; receptor protein-tyrosine kinase HEK7; tyrosine-protein kinase receptor EHK-1; 酪氨酸蛋白激酶A5受体;
背景信息:
EphA5, also known as Ehk1, Bsk, Cek7, Hek7, and Rek7, is a member of the Eph receptor family, which binds members of the Ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region is a juxtamembrane region with two tyrosines, the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the C-terminus, the latter including one conserved tyrosine.