基因名：
EPHB2
产品别名：
BDPLT22； CAPB； DRT； EK5； EPHT3； ERK； Hek5； PCBC； Tyro5； EPHB2； EPH receptor B2； EPH receptor B2； ephrin type-B receptor 2； EPH-like kinase 5； developmentally-regulated Eph-related tyrosine kinase； elk-related tyrosine kinase； eph tyrosine kinase 3； protein-tyrosine kinase HEK5； renal carcinoma antigen NY-REN-47； tyrosine-protein kinase TYRO5； tyrosine-protein kinase receptor EPH-3； 酪氨酸蛋白激酶受体B2；
背景信息：
EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia.
