基因名：
ERBB2
产品别名：
CD340； HER-2； HER-2/neu； HER2； MLN 19； NEU； NGL； TKR1； VSCN2； c-ERB-2； c-ERB2； ERBB2； erb-b2 receptor tyrosine kinase 2； erb-b2 receptor tyrosine kinase 2； receptor tyrosine-protein kinase erbB-2； c-erb B2/neu protein； herstatin； human epidermal growth factor receptor 2； metastatic lymph node gene 19 protein； neuro/glioblastoma derived oncogene homolog； neuroblastoma/glioblastoma derived oncogene homolog； proto-oncogene Neu； proto-oncogene c-ErbB-2； tyrosine kinase-type cell surface receptor HER2； v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2； v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2； v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog； ErbB2/Her2(Domain IV)蛋白； ErbB2/Her2蛋白； HER2受体； HER2受体(N端)+O11841； 磷酸化HER2受体； 神经氨酸酶(NEU)； 表皮生长因子受体2(ErbB2)；
背景信息：
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
