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重组DNA切除修复蛋白1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

重组剪切修复交叉互补修复缺陷偶联因子1(ERCC1)蛋白
Recombinant ERCC1
基因名:

ERCC1


产品别名:

COFS4; RAD10; UV20; ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit; ERCC excision repair 1, endonuclease non-catalytic subunit; DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA切除修复蛋白1; 剪切修复交叉互补修复缺陷偶联因子1(ERCC1);


背景信息:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
 
 
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