重组B组着色性干皮病偶联因子(XPB)蛋白

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重组DNA损伤修复酶ERCC3蛋白
Recombinant ERCC3

基因名：

ERCC3

产品别名：

BTF2； GTF2H； RAD25； Ssl2； TFIIH； TTD2； XPB； ERCC3； ERCC excision repair 3, TFIIH core complex helicase subunit； ERCC excision repair 3, TFIIH core complex helicase subunit； general transcription and DNA repair factor IIH helicase subunit XPB； BTF2 p89； DNA excision repair protein ERCC-3； DNA repair helicase； DNA repair protein complementing XP-B cells； TFIIH 89 kDa subunit； TFIIH basal transcription factor complex 89 kDa subunit； TFIIH basal transcription factor complex helicase XPB subunit； TFIIH p89； TFIIH subunit XPB； basic transcription factor 2 89 kDa subunit； excision repair cross-complementation group 3； excision repair cross-complementing rodent repair deficiency, complementation group 3； xeroderma pigmentosum group B-complementing protein； xeroderma pigmentosum, complementation group B； B组着色性干皮病偶联因子(XPB)； DNA损伤修复酶ERCC3蛋白；

背景信息：

Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFIIH. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of 5 subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.