基因名：
ESR1
产品别名：
ER； ESR； ESRA； ESTRR； Era； NR3A1； ESR1； estrogen receptor 1； estrogen receptor 1； estrogen receptor； E2 receptor alpha； ER-alpha； estradiol receptor； estrogen nuclear receptor alpha； estrogen receptor alpha E1-E2-1-2； estrogen receptor alpha E1-N2-E2-1-2； nuclear receptor subfamily 3 group A member 1； oestrogen receptor alpha； 磷酸化雌激素受体ER alpha； 磷酸化雌激素受体α； 雌激素受体α； 雌激素受体α(ERa)； 雌激素受体α/β； 雌激素受体α36；
背景信息：
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
