基因名：
EZH1
产品别名：
KMT6B； EZH1； enhancer of zeste 1 polycomb repressive complex 2 subunit； enhancer of zeste 1 polycomb repressive complex 2 subunit； histone-lysine N-methyltransferase EZH1； ENX-2； enhancer of zeste homolog 1； Zeste同源物增强子1(EZH1)； 组蛋白赖氨酸N-甲基EZH1；
背景信息：
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Sequence similarities
Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 SET domain.
