基因名：
PTK2B
产品别名：
CADTK； CAKB； FADK2； FAK2； PKB； PTK； PYK2； RAFTK； PTK2B； protein tyrosine kinase 2 beta； protein tyrosine kinase 2 beta； protein-tyrosine kinase 2-beta； CAK-beta； FADK 2； PTK2B protein tyrosine kinase 2 beta； calcium-dependent tyrosine kinase； calcium-regulated non-receptor proline-rich tyrosine kinase； cell adhesion kinase beta； focal adhesion kinase 2； proline-rich tyrosine kinase 2； protein kinase B； related adhesion focal tyrosine kinase； 富含脯氨酸的酪氨酸激酶2； 磷酸化富含脯氨酸的酪氨酸激酶2； 蛋白酪氨酸激酶2β(PYK2)；
背景信息：
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
