基因名：
FCGR2B
产品别名：
CD32； CD32B； FCG2； FCGR2； FCGR2C； FcGRIIB； FcRII-c； FcgammaRIIb； IGFR2； FCGR2B； Fc gamma receptor IIb； Fc gamma receptor IIb； low affinity immunoglobulin gamma Fc region receptor II-b； CDw32； Fc fragment of IgG receptor IIb； Fc fragment of IgG, low affinity II, receptor for (CD32)； Fc fragment of IgG, low affinity IIb, receptor (CD32)； Fc fragment of IgG, low affinity IIb, receptor for (CD32)； Fc gamma RIIb； Fc-gamma RII-c； Fc-gamma-RIIc； IgG Fc receptor II-c； Low affinity immunoglobulin gamma Fc region receptor II-c； fc-gamma RII-b； fc-gamma-RIIb； fcRII-b； igG Fc receptor II-b；
背景信息：
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.
