基因名：
FKBP3
产品别名：
FKBP-25； FKBP-3； FKBP25； PPIase； FKBP3； FKBP prolyl isomerase 3； FKBP prolyl isomerase 3； peptidyl-prolyl cis-trans isomerase FKBP3； 25 kDa FK506-binding protein； 25 kDa FKBP； FK506 binding protein 3, 25kDa； FK506-binding protein 25, T-cell； FK506-binding protein 3； PPIase FKBP3； immunophilin FKBP25； rapamycin binding protein； rapamycin-selective 25 kDa immunophilin； rotamase； FK506结合蛋白3(FKBP3)； 肽基脯氨酸异构酶酶FKBP25；
背景信息：
FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
