基因名:
FOXE1
产品别名:
FKHL15; FOXE2; HFKH4; HFKL5; NMTC4; TITF2; TTF-2; TTF2; FOXE1; forkhead box E1; forkhead box E1; forkhead box protein E1; HNF-3/fork head-like protein 5; forkhead box protein E2; forkhead, drosophila, homolog-like 15; forkhead-related protein FKHL15; thyroid transcription factor 2; 叉头框蛋白E1(FOXE1); 甲状腺转录因子-2;
背景信息:
Thyroid transcription factor 2 (TITF2; Forkhead; TH; also known as a "winged helix") . FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. TISSUE SPECIFICITY: Thyroid and lung. subcellular location: Nucleus Belongs to the NK-2 homeobox family.