基因名：
FLI1
产品别名：
BDPLT21； EWSR2； FLI-1； SIC-1； FLI1； Fli-1 proto-oncogene, ETS transcription factor； Fli-1 proto-oncogene, ETS transcription factor； Friend leukemia integration 1 transcription factor； Ewing sarcoma breakpoint region 2； Friend leukemia virus integration 1； transcription factor ERGB； 佛氏白血病病毒整合蛋白1(FLI1)； 尤文肉瘤FLI1蛋白；
背景信息：
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Involvement in diseaseDefects in FLI1 are a cause of Ewing sarcoma (ES) . A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.
