基因名：
FMO3
产品别名：
FMOII； TMAU； dJ127D3.1； FMO3； flavin containing dimethylaniline monoxygenase 3； flavin containing dimethylaniline monoxygenase 3； dimethylaniline monooxygenase [N-oxide-forming] 3； FMO form 2； dimethylaniline oxidase 3； flavin containing monooxygenase 3； hepatic flavin-containing monooxygenase-3； trimethylamine monooxygenase； 二甲基苯胺单加氧酶3； 含黄素单加氧酶3(FMO3)；
背景信息：
The Flavin containing monooxygenase family consists of five gene products, FMO1-5, that are major enzymatic oxidants involved in the metabolism of various therapeutics. Located in the liver, FMO3 is a hepatic microsomal enzyme that oxygenates soft nucleophiles such as secondary and tertiary amines. Through its N-oxygenase capabilities, FMO3 acts on a variety of xenobiotics to catalyze oxidative digestion. Defects in the FMO3 gene are the primary cause of trimethylaminuria (TMAuria), an inborn error of metabolism associated with a fishy body odor emitting from sweat, urine and breath. Genetic mutations in FMO3 lead to the N-oxidation of amino-trimethylamine derived from food products, thus producing the malodor associated with TMAuria.
